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Kashin-Beck disease

MedGen UID:
412531
•Concept ID:
C2745963
•
Disease or Syndrome
Synonyms: Disease, Kashin-Beck; Kashin Beck Disease; Kashin-Beck Disease
SNOMED CT: Kashin-Beck disease (270505009); Endemic polyarthritis (270505009); Kaschin-Beck disease (270505009); Urov disease (270505009); Kashin-Bek disease (270505009)
 
Monarch Initiative: MONDO:0005610

Definition

Disabling osteochondrodysplasia with osteosclerosis, cone-shaped metaphysis, and shortening of the diaphysis. It is endemic in parts of Siberia and northern China. Mineral deficiencies (e.g., selenium, iodine), fungal cereal contamination, and water contamination may be contributing factors in its etiology. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKashin-Beck disease

Professional guidelines

PubMed

Effects of five types of selenium supplementation for treatment of Kashin-Beck disease in children: a systematic review and network meta-analysis.
Xie D, Liao Y, Yue J, Zhang C, Wang Y, Deng C, Chen L
BMJ Open 2018 Mar 6;8(3):e017883. doi: 10.1136/bmjopen-2017-017883. PMID: 29511006Free PMC Article
Evaluation of the therapeutic effect of treatment with intra-articular hyaluronic acid in knees for Kashin-Beck disease: a meta-analysis.
Yu FF, Xia CT, Fang H, Han J, Younus MI, Guo X
Osteoarthritis Cartilage 2014 Jun;22(6):718-25. Epub 2014 Apr 30 doi: 10.1016/j.joca.2014.04.012. PMID: 24792210
Sodium selenite for treatment of Kashin-Beck disease in children: a systematic review of randomised controlled trials.
Jirong Y, Huiyun P, Zhongzhe Y, Birong D, Weimin L, Ming Y, Yi S
Osteoarthritis Cartilage 2012 Jul;20(7):605-13. Epub 2012 Feb 24 doi: 10.1016/j.joca.2012.02.012. PMID: 22370124

Recent clinical studies

Etiology

The Prevalence of Kashin-Beck Disease in China: a Systematic Review and Meta-analysis.
Xu J, Wang J, Zhao H
Biol Trace Elem Res 2023 Jul;201(7):3175-3184. Epub 2022 Sep 15 doi: 10.1007/s12011-022-03417-x. PMID: 36104539
Meta-analysis of Association Studies of Selenoprotein Gene Polymorphism and Kashin-Beck Disease: an Updated Systematic Review.
Yu FF, Sun L, Zhou GY, Ping ZG, Guo X, Ba Y
Biol Trace Elem Res 2022 Feb;200(2):543-550. Epub 2021 Apr 12 doi: 10.1007/s12011-021-02705-2. PMID: 33844169
Comparison of the major cell populations among osteoarthritis, Kashin-Beck disease and healthy chondrocytes by single-cell RNA-seq analysis.
Wang X, Ning Y, Zhang P, Poulet B, Huang R, Gong Y, Hu M, Li C, Zhou R, Lammi MJ, Guo X
Cell Death Dis 2021 May 27;12(6):551. doi: 10.1038/s41419-021-03832-3. PMID: 34045450Free PMC Article
Pathway-based network analyses and candidate genes associated with Kashin-Beck disease.
Zhang R, Guo H, Yang X, Zhang D, Li B, Li Z, Xiong Y
Medicine (Baltimore) 2019 May;98(18):e15498. doi: 10.1097/MD.0000000000015498. PMID: 31045836Free PMC Article
Selenium, iodine, and the relation with Kashin-Beck disease.
Yao Y, Pei F, Kang P
Nutrition 2011 Nov-Dec;27(11-12):1095-100. doi: 10.1016/j.nut.2011.03.002. PMID: 21967994

Diagnosis

Clinical and Radiographic Features of the Atlantoaxial Dislocation Associated With Kashin-Beck Disease.
Wang Y, Song C, Ji Y, Xia J, Chen C, Haque M, Zhuang J, Zhou C, Zu J, Li X, Yan J
World Neurosurg 2023 Mar;171:e1-e7. Epub 2022 Aug 29 doi: 10.1016/j.wneu.2022.08.108. PMID: 36049725
Growth surveillance indices and Kashin-Beck Disease in children.
马玮娟 Ma Wei Juan
J Med Life 2022 Feb;15(2):292-297. doi: 10.25122/jml-2021-0125. PMID: 35419096Free PMC Article
Status and potential diagnostic roles of essential trace elements in Kashin- Beck disease patients.
Fu G, Chen X, Qi M, Du X, Xia Z, Liu Q, Sun N, Shi C, Zhang R
J Trace Elem Med Biol 2022 Jan;69:126880. Epub 2021 Oct 25 doi: 10.1016/j.jtemb.2021.126880. PMID: 34717166
Comparison of the major cell populations among osteoarthritis, Kashin-Beck disease and healthy chondrocytes by single-cell RNA-seq analysis.
Wang X, Ning Y, Zhang P, Poulet B, Huang R, Gong Y, Hu M, Li C, Zhou R, Lammi MJ, Guo X
Cell Death Dis 2021 May 27;12(6):551. doi: 10.1038/s41419-021-03832-3. PMID: 34045450Free PMC Article
Pathway-based network analyses and candidate genes associated with Kashin-Beck disease.
Zhang R, Guo H, Yang X, Zhang D, Li B, Li Z, Xiong Y
Medicine (Baltimore) 2019 May;98(18):e15498. doi: 10.1097/MD.0000000000015498. PMID: 31045836Free PMC Article

Therapy

The Prevalence of Kashin-Beck Disease in China: a Systematic Review and Meta-analysis.
Xu J, Wang J, Zhao H
Biol Trace Elem Res 2023 Jul;201(7):3175-3184. Epub 2022 Sep 15 doi: 10.1007/s12011-022-03417-x. PMID: 36104539
Endemic Kashin-Beck disease: A food-sourced osteoarthropathy.
Wang K, Yu J, Liu H, Liu Y, Liu N, Cao Y, Zhang X, Sun D
Semin Arthritis Rheum 2020 Apr;50(2):366-372. Epub 2019 Aug 2 doi: 10.1016/j.semarthrit.2019.07.014. PMID: 31548049
Selenium.
Prabhu KS, Lei XG
Adv Nutr 2016 Mar;7(2):415-7. Epub 2016 Mar 15 doi: 10.3945/an.115.010785. PMID: 26980826Free PMC Article
Selenium and thyroid.
Köhrle J, Gärtner R
Best Pract Res Clin Endocrinol Metab 2009 Dec;23(6):815-27. doi: 10.1016/j.beem.2009.08.002. PMID: 19942156
Kashin-Beck disease.
Kolsteren P
Ann Soc Belg Med Trop 1992 Jun;72(2):81-91. PMID: 1417163

Prognosis

Integration of miRNA in exosomes and single-cell RNA-seq profiles in endemic osteoarthritis, Kashin-Beck disease.
Wang X, Zhang Y, Wu Y, Wang C, Li S, Yuan Y, Lv X, Liu Y, Chen F, Chen S, Zhang F, Guo X, Ning Y, Zhao H
Biofactors 2024 Jul-Aug;50(4):725-737. Epub 2023 Dec 29 doi: 10.1002/biof.2033. PMID: 38156801
Growth surveillance indices and Kashin-Beck Disease in children.
马玮娟 Ma Wei Juan
J Med Life 2022 Feb;15(2):292-297. doi: 10.25122/jml-2021-0125. PMID: 35419096Free PMC Article
LncRNAs as a new regulator of chronic musculoskeletal disorder.
Huang H, Xing D, Zhang Q, Li H, Lin J, He Z, Lin J
Cell Prolif 2021 Oct;54(10):e13113. Epub 2021 Sep 8 doi: 10.1111/cpr.13113. PMID: 34498342Free PMC Article
Endemic Kashin-Beck disease: A food-sourced osteoarthropathy.
Wang K, Yu J, Liu H, Liu Y, Liu N, Cao Y, Zhang X, Sun D
Semin Arthritis Rheum 2020 Apr;50(2):366-372. Epub 2019 Aug 2 doi: 10.1016/j.semarthrit.2019.07.014. PMID: 31548049
Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease.
Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ
Osteoarthritis Cartilage 2014 Nov;22(11):1774-83. Epub 2014 Aug 12 doi: 10.1016/j.joca.2014.07.023. PMID: 25106677

Clinical prediction guides

The Prevalence of Kashin-Beck Disease in China: a Systematic Review and Meta-analysis.
Xu J, Wang J, Zhao H
Biol Trace Elem Res 2023 Jul;201(7):3175-3184. Epub 2022 Sep 15 doi: 10.1007/s12011-022-03417-x. PMID: 36104539
Clinical and Radiographic Features of the Atlantoaxial Dislocation Associated With Kashin-Beck Disease.
Wang Y, Song C, Ji Y, Xia J, Chen C, Haque M, Zhuang J, Zhou C, Zu J, Li X, Yan J
World Neurosurg 2023 Mar;171:e1-e7. Epub 2022 Aug 29 doi: 10.1016/j.wneu.2022.08.108. PMID: 36049725
Growth surveillance indices and Kashin-Beck Disease in children.
马玮娟 Ma Wei Juan
J Med Life 2022 Feb;15(2):292-297. doi: 10.25122/jml-2021-0125. PMID: 35419096Free PMC Article
Proteoglycan metabolism, cell death and Kashin-Beck disease.
Li S, Cao J, Caterson B, Hughes CE
Glycoconj J 2012 Aug;29(5-6):241-8. Epub 2012 Jun 26 doi: 10.1007/s10719-012-9421-2. PMID: 22733148Free PMC Article
Kashin-Beck disease: from etiology to prevention or from prevention to etiology?
Sudre P, Mathieu F
Int Orthop 2001;25(3):175-9. doi: 10.1007/s002640000179. PMID: 11482536Free PMC Article

Recent systematic reviews

The Prevalence of Kashin-Beck Disease in China: a Systematic Review and Meta-analysis.
Xu J, Wang J, Zhao H
Biol Trace Elem Res 2023 Jul;201(7):3175-3184. Epub 2022 Sep 15 doi: 10.1007/s12011-022-03417-x. PMID: 36104539
Meta-analysis of Association Studies of Selenoprotein Gene Polymorphism and Kashin-Beck Disease: an Updated Systematic Review.
Yu FF, Sun L, Zhou GY, Ping ZG, Guo X, Ba Y
Biol Trace Elem Res 2022 Feb;200(2):543-550. Epub 2021 Apr 12 doi: 10.1007/s12011-021-02705-2. PMID: 33844169
Effects of five types of selenium supplementation for treatment of Kashin-Beck disease in children: a systematic review and network meta-analysis.
Xie D, Liao Y, Yue J, Zhang C, Wang Y, Deng C, Chen L
BMJ Open 2018 Mar 6;8(3):e017883. doi: 10.1136/bmjopen-2017-017883. PMID: 29511006Free PMC Article
Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin-Beck disease.
Yu FF, Zhang YX, Zhang LH, Li WR, Guo X, Lammi MJ
Medicine (Baltimore) 2016 Dec;95(52):e5669. doi: 10.1097/MD.0000000000005669. PMID: 28033256Free PMC Article
Sodium selenite for treatment of Kashin-Beck disease in children: a systematic review of randomised controlled trials.
Jirong Y, Huiyun P, Zhongzhe Y, Birong D, Weimin L, Ming Y, Yi S
Osteoarthritis Cartilage 2012 Jul;20(7):605-13. Epub 2012 Feb 24 doi: 10.1016/j.joca.2012.02.012. PMID: 22370124

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